Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment
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Date
2010Author
Graham, Susan M.
Masese, Linnet
Gitau, Ruth
Jalalian-Lechak, Zahra
Richardson, Barbra A.
Peshu, Norbert
Mandaliya, Kishor
Kiarie, James N.
Jaoko Walter G.
Ndinya-Achola, JO
Overbaugh, Julie
McClelland, R. Scott
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Persistent genital human immunodeficiency virus type 1
(HIV-1) shedding among women receiving antiretroviral
therapy (ART) may present a transmission risk. We investigated
the associations between genital HIV-1 suppression
after ART initiation and adherence, resistance, pretreatment
CD4 cell count, and hormonal contraceptive use. First-line
ART was initiated in 102 women. Plasma and genital HIV-
1 RNA levels were measured at months 0, 3, and 6. Adherence
was a strong and consistent predictor of genital HIV-1 suppression
(P ! .001), whereas genotypic resistance was associated
with higher vaginal HIV-1 RNA level at month 6
(Pp.04). These results emphasize the importance of adherence
to optimize the potential benefits of ART for reducing
HIV-1 transmission risk.
URI
http://www.ncbi.nlm.nih.gov/pubmed/20923373http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9957
Citation
JID 2010:202Collections
- Faculty of Health Sciences (FHS) [10377]