A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
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Date
2009Author
Oyugi, Julius O.
Vouriot, Françoise C. M.
Alimonti, Judie
Wayne, Stephen
Luo, Ma
Land, Allison M.
AO, Zhujun
Yao, Xiaojian
Sekaly, Rafick P.
Elliott, Lawrence J.
Simonsen, J. Neil
Ball, T. Blake
Jaoko Walter G.
Kimani, Joshua
Plummer, Francis A.
Fowke, Keith R.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has
been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to human immunodeficiency virus (HIV) infection. Overall, the present study found a strong correlation between CD4 C868T and increased susceptibility
to HIV-1 infection. Given the high prevalence of both HIV infection and CD4 C868T in African populations, the effect of this SNP on the epidemic in Africa could be dramatic
URI
http://www.ncbi.nlm.nih.gov/pubmed/19301975http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10111
Citation
CD4 Polymorphism and HIV-1 InfectionCollections
- Faculty of Health Sciences (FHS) [10387]