Translactonization in Erythromycins
Date
1987Author
Kibwage, IO
Busson, R
Janssen, G
Hoogmartens, J
Vanderhaeghe, H
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
When erythromycin A is heated in diethylamine-acetic acid. an erythromycin hemiketal is obtained, which can be further transformed into a new enol ether and spiroketal. The new euol ether is also obtained in equilibrium with the normal one on heating erythromycin A or B in pyridine-acetic acid. The novel compounds. which will be called pseudoerythromycin derivatives. are characterized by a translactonization between the eu-hydroxyl and the lactone group. Their structure was proved by mass and IH and 13C NMR spectrometry. by acetylation experiments, and by degradation with lead tetraacetate.
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