Bone metabolism in healthy ambulatory control pre-menopausal women and in epileptics on anti-convulsant drugs
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Date
2010Author
Kwasa, J K
Amayo, A
Ndavi, P M
Kwasa, Thomas O O
Type
ArticleLanguage
enMetadata
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Background: Long term anti-epileptic drug use causes multiple abnormalities in calcium and bone metabolism that have been documented in both institutionalised and ambulatory patients.
Objective: To assess bone metabolism in ambulatory females of reproductive age, on antiepileptic drugs.
Design: Cross sectional comparative study.
Subjects: Ambulatory females in reproductive age group with epilepsy and on regular follow up were compared to healthy females of similar ages not on any treatment. Results: The mean duration of treatment for epilepsy was eight years (±6.3). Majority of the patients were on enzyme inducing drugs like phenobarbital, phenytoin, carbamazepine and valproate, either alone orin combination with non-enzyme inducers like lamotrigine (98.2%). There was a significantly lower mean serum calcium and a higher alkaline phosphatase level among the patients (P=0.002 and 0.0001 respectively) than among the comparators. The urinary marker of bone loss (mean urine calcium excretion) was also significantly raised among the patients (P=0.003). The mean lumbar BMDT-score results were not significantly different in the two groups.
Conclusions: Long-term anti-epileptic drug use significantly affects biochemical parameters of bone metabolism. These effects on bone biochemistry markers were not reflected in lumbar spine BMD in this study.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10418http://www.ncbi.nlm.nih.gov/pubmed/23057290
Citation
East African Medical Journal Vol. 87 No.4 April 2010Collections
- Faculty of Health Sciences (FHS) [10387]