dc.contributor.author | Kwasa, J K | |
dc.contributor.author | Amayo, A | |
dc.contributor.author | Ndavi, P M | |
dc.contributor.author | Kwasa, Thomas O O | |
dc.date.accessioned | 2013-02-20T08:24:20Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | East African Medical Journal Vol. 87 No.4 April 2010 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10418 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23057290 | |
dc.description.abstract | Background: Long term anti-epileptic drug use causes multiple abnormalities in calcium and bone metabolism that have been documented in both institutionalised and ambulatory patients.
Objective: To assess bone metabolism in ambulatory females of reproductive age, on antiepileptic drugs.
Design: Cross sectional comparative study.
Subjects: Ambulatory females in reproductive age group with epilepsy and on regular follow up were compared to healthy females of similar ages not on any treatment. Results: The mean duration of treatment for epilepsy was eight years (±6.3). Majority of the patients were on enzyme inducing drugs like phenobarbital, phenytoin, carbamazepine and valproate, either alone orin combination with non-enzyme inducers like lamotrigine (98.2%). There was a significantly lower mean serum calcium and a higher alkaline phosphatase level among the patients (P=0.002 and 0.0001 respectively) than among the comparators. The urinary marker of bone loss (mean urine calcium excretion) was also significantly raised among the patients (P=0.003). The mean lumbar BMDT-score results were not significantly different in the two groups.
Conclusions: Long-term anti-epileptic drug use significantly affects biochemical parameters of bone metabolism. These effects on bone biochemistry markers were not reflected in lumbar spine BMD in this study. | en |
dc.language.iso | en | en |
dc.subject | Pre-menopausal | en |
dc.subject | Bone metabolism | en |
dc.subject | Women | en |
dc.title | Bone metabolism in healthy ambulatory control pre-menopausal women and in epileptics on anti-convulsant drugs | en |
dc.type | Article | en |