| dc.contributor.author | Paesen, J. | |
| dc.contributor.author | Quintens, I. | |
| dc.contributor.author | Thoithi, G. | |
| dc.contributor.author | Roets, E. | |
| dc.contributor.author | Reybrouck, G. | |
| dc.contributor.author | Hoogmartens, J. | |
| dc.date.accessioned | 2013-02-21T14:22:28Z | |
| dc.date.issued | 1994 | |
| dc.identifier.citation | Journal of Chromatography A, 677 (1994) 377-384 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10643 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/7921189 | |
| dc.description.abstract | A thin-layer chromatography method for quantitative analysis of quaternary ammonium antiseptics is described.
Silanized silica gel was used as the stationary phase. The moille phase consisted of mcthal101-15rc (rn/v) sodium acetate solution-acetone (65:35:20). The method is able to separate the chain homologues of benzalkonium chloride, cetylpyridinium chloride and cetrimide. Detection was performed using a colour reaction with potassium triiodide solution. The different homologues were quantified using UV densitometry at 400 nm. A number of commercial samples was analysed using this method. From the results it appears that it is worthwhile to have a limit test for the composition of quaternary ammonium antiseptics in pharmacopoeial monograph, the more so as the antibacterial activity depends on it. | en |
| dc.language.iso | en | en |
| dc.title | Quantitative analysis of quaternary ammonium antiseptics using thin-layer densitometry | en |
| dc.type | Article | en |
| local.embargo.terms | 6 months | en |
| local.publisher | Cathollc University of Leiuven, | en |
| local.publisher | Laboratory for Pharmaceutical Chemistry; | en |
| local.publisher | Faculty of Pharmaceutical Sciences. | en |
| local.publisher | School of Public Health, Faculty of Medicine, | en |
