The effects of chronic clomipramine and mianserin on the activity of tryptophan hydroxylase in the rat brain
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Date
1993Author
Sinei, K.A.
Redfern, P.H
Type
ArticleLanguage
enMetadata
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The activity of tryptophan hydroxylase was measured in the rat brainstrem and cortex by the rat of in vivo accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase with 3-hydroxybenzyl-hydrazine.The activity of the enzyme was higher at mid-dark than mid-light in the two brain areas.Chronic administration of clomipramine increased the enzymatic activity at the two time of day to different levels of significance.In contrast chronic mianserin led to a decrease but only to different levels of significance in the cortex.The significance of these results are discussed in relation to the theories implicating circadian rythms in the mechanism of anti-depressant action
Citation
East African Medical Journal Vol. 70 No.11 November 1993Publisher
Department of Pharmacy, College of Health Sciences, University of Nairobi
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- Faculty of Health Sciences (FHS) [10378]