| dc.contributor.author | Sinei, K.A. | |
| dc.contributor.author | Redfern, P.H | |
| dc.date.accessioned | 2013-02-22T12:50:52Z | |
| dc.date.issued | 1993 | |
| dc.identifier.citation | East African Medical Journal Vol. 70 No.11 November 1993 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10779 | |
| dc.description.abstract | The activity of tryptophan hydroxylase was measured in the rat brainstrem and cortex by the rat of in vivo accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase with 3-hydroxybenzyl-hydrazine.The activity of the enzyme was higher at mid-dark than mid-light in the two brain areas.Chronic administration of clomipramine increased the enzymatic activity at the two time of day to different levels of significance.In contrast chronic mianserin led to a decrease but only to different levels of significance in the cortex.The significance of these results are discussed in relation to the theories implicating circadian rythms in the mechanism of anti-depressant action | en |
| dc.language.iso | en | en |
| dc.title | The effects of chronic clomipramine and mianserin on the activity of tryptophan hydroxylase in the rat brain | en |
| dc.type | Article | en |
| local.embargo.terms | 6 months | en |
| local.publisher | Department of Pharmacy, College of Health Sciences, University of Nairobi | en |
