Effects of the active constituents of catha edulis on the neuromuscular junction
Date
1986Author
Guantai Anastacia N.
Mwangi, J.W
Muriuki, Gichuru
Kuria, K.A.M.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
-( - )-Cathinone and d-norpseudoephedrine (ONE) in the dose range 0.2-1.2 mg/ml produced a reduction in contractions of skeletal muscle, evoked by direct and indirect electrical stimulation and antagonised the facilitatory action of physostigmine on the neuromuscular junction; but failed to antagonise a partial blockade induced by d-tubocurarine (dTb) as occurs with norepinephrine or epinephrine. The local anaesthetic actions of ( - )-cathinone and ONE were found to be almost equivalent to that of lignocaine.
These results indicate that (- )-cathinone and ONE may have a direct blocking action on the
neuromuscular junction, which is independent of cholinergic and adrenergic transmission.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11035http://www.ncbi.nlm.nih.gov/pubmed/3037411
Citation
Neuropharmacology Vol.26 No.5 pp 410-405,1987Publisher
Mitishamba Drug Research Centre, Department of Pharmacy, College of Health Sciences, University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10377]