| dc.contributor.author | Guantai Anastacia N. | |
| dc.contributor.author | Mwangi, J.W | |
| dc.contributor.author | Muriuki, Gichuru | |
| dc.contributor.author | Kuria, K.A.M. | |
| dc.date.accessioned | 2013-02-25T06:34:05Z | |
| dc.date.issued | 1986 | |
| dc.identifier.citation | Neuropharmacology Vol.26 No.5 pp 410-405,1987 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11035 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/3037411 | |
| dc.description.abstract | -( - )-Cathinone and d-norpseudoephedrine (ONE) in the dose range 0.2-1.2 mg/ml produced a reduction in contractions of skeletal muscle, evoked by direct and indirect electrical stimulation and antagonised the facilitatory action of physostigmine on the neuromuscular junction; but failed to antagonise a partial blockade induced by d-tubocurarine (dTb) as occurs with norepinephrine or epinephrine. The local anaesthetic actions of ( - )-cathinone and ONE were found to be almost equivalent to that of lignocaine.
These results indicate that (- )-cathinone and ONE may have a direct blocking action on the
neuromuscular junction, which is independent of cholinergic and adrenergic transmission. | en |
| dc.language.iso | en | en |
| dc.subject | Catha edulis, | en |
| dc.subject | Active constituents, | en |
| dc.subject | Neuromuscular junction. | en |
| dc.title | Effects of the active constituents of catha edulis on the neuromuscular junction | en |
| dc.type | Article | en |
| local.embargo.terms | 6 months | en |
| local.publisher | Mitishamba Drug Research Centre, Department of Pharmacy, College of Health Sciences, University of Nairobi, | en |
