dc.contributor.author | Slyker, Jennifer A. | |
dc.contributor.author | Lohman-Payne, Barbara L. | |
dc.contributor.author | Rowland-Jones, Sarah L. | |
dc.contributor.author | Otieno, Phelgona | |
dc.contributor.author | Maleche-Obimbo, Elizabeth | |
dc.contributor.author | Richardson, Barbra | |
dc.contributor.author | Farquhar, Carey | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Emery, Vincent C. | |
dc.contributor.author | John-Stewart, Grace C. | |
dc.date.accessioned | 2013-02-25T10:10:47Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | AIDS | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11152 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19050393 | |
dc.description.abstract | Objective—Cytomegalovirus (CMV) is an important pathogen in healthy neonates and individuals
with human immunodeficiency virus (HIV-1). The objective of this study was to determine whether
the detection of CMV DNA (CMV DNAemia) in maternal plasma was associated with mortality in
HIV-1 infected women or their infants.
Methods—A longitudinal study was designed to examine the relationship between maternal CMV
DNAemia and maternal-infant mortality during two years postpartum. Sixty-four HIV-1 infected
women and their infants were studied. CMV DNA loads were quantified in plasma from the mothers
near the time of delivery. Baseline maternal CD4 counts, CD4%, HIV-1 RNA, and CMV DNAemia
were evaluated as covariates of subsequent maternal or infant mortality in univariate and multivariate
Cox regression.
Results—CMV DNA was detected in 11/64 (17%) of the HIV-1 infected women. HIV-1 and CMV
viral load were strongly correlated in CMV DNAemic women (ρ=0.84, p=0.001). Detection of CMV
DNAemia was associated with decreased maternal survival at 24 months postpartum (log-rank
p=0.006). Additionally, HIV-1 infected infants born to CMV DNAemic women had a 4-fold
increased risk of mortality during 24 months of follow-up. Maternal CMV DNAemia remained a
significant risk factor for mortality in HIV-1 infected infants after adjusting for maternal CD4 cells/
mm3 (adjusted HR=4.3, CI=1.4–13), CD4% (HR=3.2, CI=1.0–10), HIV-1 viral load (HR=4.1,
CI=1.4–12) or maternal death (HR=3.7, CI=1.0–13). | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | 2; 23(1): 117–124; | |
dc.subject | cytomegalovirus; vertical transmission; viral load; infant mortality | en |
dc.title | The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1 infected women and their infants | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics, University of Nairobi, Nairobi, Kenya | en |