dc.contributor.author | Marangu, Diana | |
dc.contributor.author | Diane, Gray | |
dc.contributor.author | Aneesa, Vanker | |
dc.contributor.author | Marco, Zampoli | |
dc.date.accessioned | 2020-11-02T08:06:56Z | |
dc.date.available | 2020-11-02T08:06:56Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Marangu D, Gray D, Vanker A, Zampoli M. Exogenous lipoid pneumonia in children: A systematic review. Paediatr Respir Rev. 2020 Feb;33:45-51. doi: 10.1016/j.prrv.2019.01.001. Epub 2019 Jan 20. PMID: 30962152; PMCID: PMC7106224. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/30962152/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153248 | |
dc.description.abstract | Objectives: To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).
Design: Systematic review. We searched electronic databases and reference lists published between 1967 and 2018, restricted to non-accidental cases.
Results: Forty-four studies including 489 participants aged 1 day to 17 years from 13 countries were included. Cultural, medical, and behavioural rationale for oil-use was described. The clinical-radiological presentation varied widely. Diagnostic certainty was deemed highest if ELP was confirmed on bronchoalveolar lavage/frozen section lung biopsy with documented extracellular lipid on cytological staining and/or fat analysis. Non-tuberculous mycobacteria infection was identified in six studies: Mycobacterium fortuitum/chelonei, Mycobacterium smegmatis and Mycobacterium abscessus. Treatment comprised supportive therapy, corticosteroids, stopping oil, therapeutic lung-lavage and surgical resection. Outcomes were reported inconsistently.
Conclusion: Paediatric ELP resulting from cultural and medical practices continues to be described globally. Preventive interventions, standardized reporting, and treatment efficacy studies for cases not averted, are lacking. Protocol registration: PROSPERO CRD42017068313. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Children’s interstitial lung disease (chILD); Global Health; Oil. | en_US |
dc.title | Exogenous lipoid pneumonia in children: A systematic review | en_US |
dc.type | Article | en_US |