Exogenous lipoid pneumonia in children: A systematic review
Date
2020Author
Marangu, Diana
Diane, Gray
Aneesa, Vanker
Marco, Zampoli
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Objectives: To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).
Design: Systematic review. We searched electronic databases and reference lists published between 1967 and 2018, restricted to non-accidental cases.
Results: Forty-four studies including 489 participants aged 1 day to 17 years from 13 countries were included. Cultural, medical, and behavioural rationale for oil-use was described. The clinical-radiological presentation varied widely. Diagnostic certainty was deemed highest if ELP was confirmed on bronchoalveolar lavage/frozen section lung biopsy with documented extracellular lipid on cytological staining and/or fat analysis. Non-tuberculous mycobacteria infection was identified in six studies: Mycobacterium fortuitum/chelonei, Mycobacterium smegmatis and Mycobacterium abscessus. Treatment comprised supportive therapy, corticosteroids, stopping oil, therapeutic lung-lavage and surgical resection. Outcomes were reported inconsistently.
Conclusion: Paediatric ELP resulting from cultural and medical practices continues to be described globally. Preventive interventions, standardized reporting, and treatment efficacy studies for cases not averted, are lacking. Protocol registration: PROSPERO CRD42017068313.
Citation
Marangu D, Gray D, Vanker A, Zampoli M. Exogenous lipoid pneumonia in children: A systematic review. Paediatr Respir Rev. 2020 Feb;33:45-51. doi: 10.1016/j.prrv.2019.01.001. Epub 2019 Jan 20. PMID: 30962152; PMCID: PMC7106224.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10378]
The following license files are associated with this item: