Association between Vaginal Bacterial Microbiota and Vaginal Yeast Colonization
Date
2020Author
Eastment, McKenna C
Balkus, Jennifer E
Richardson, Barbra A
Srinivasan, Sujatha
Kimani, Joshua
Anzala, Omu
Schwebke, Jane
Fiedler, Tina L
Fredricks, David N
McClelland, R Scott
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Background: Vaginal yeast is frequently found with Lactobacillus-dominant microbiota. The relationship between vaginal yeast and other bacteria has not been well characterized.
Methods: These analyses utilized data from the Preventing Vaginal Infections trial. Relative abundance of vaginal bacteria from 16S rRNA gene amplicon sequencing and quantities of 10 vaginal bacteria using taxon-directed PCR assays were compared at visits with and without detection of yeast on microscopy, culture, or both.
Results: Higher relative abundances of Megasphaera species type 1 (RR 0.70, 95%CI 0.52-0.95), Megasphaera species type 2 (RR 0.81, 95%CI 0.67-0.98) and Mageeibacillus indolicus (RR 0.46, 95%CI 0.25-0.83), were associated with lower risk of detecting yeast. Conversely, higher relative abundances of Bifidobacterium bifidum, Aerococcus christensenii, Lactobacillus mucosae, Streptococcus equinus/infantarius/lutentiensis, Prevotella bivia, Dialister propionicifaciens, and Lactobacillus crispatus/helveticus were associated with yeast detection. Taxon-directed assays confirmed that increasing quantities of both Megasphaera species and M. indolicus were associated with lower risk of detecting yeast while, increasing quantities of L. crispatus were associated with higher risk of detecting yeast.
Conclusion: Despite an analysis that examined associations between multiple vaginal bacteria and the presence of yeast, only a small number of vaginal bacteria were strongly and significantly associated with the presence or absence of yeast.
Citation
Eastment MC, Balkus JE, Richardson BA, Srinivasan S, Kimani J, Anzala O, Schwebke J, Fiedler TL, Fredricks DN, McClelland RS. Association between Vaginal Bacterial Microbiota and Vaginal Yeast Colonization. J Infect Dis. 2020 Jul 29:jiaa459. doi: 10.1093/infdis/jiaa459. Epub ahead of print. PMID: 32726445.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10387]
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