dc.contributor.author | Buyinza, Daniel | |
dc.contributor.author | Yang, Li Jun | |
dc.contributor.author | Derese, Solomon | |
dc.contributor.author | Ndakala, Albert | |
dc.contributor.author | Coghi, Paolo | |
dc.contributor.author | Heydenreich, Matthias | |
dc.contributor.author | Wong, Vincent K W | |
dc.contributor.author | Möller, Heiko M | |
dc.contributor.author | Yenesew, Abiy | |
dc.date.accessioned | 2021-09-29T05:33:19Z | |
dc.date.available | 2021-09-29T05:33:19Z | |
dc.date.issued | 2021-08 | |
dc.identifier.citation | Nat Prod Res . 2021 Aug;35(16):2744-2747 | en_US |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155534 | |
dc.description.abstract | The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM). | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Leguminosae; Millettia dura; cytotoxicity; isoflavone. | en_US |
dc.title | Cytotoxicity of isoflavones from Millettia dura | en_US |
dc.type | Article | en_US |