Cytotoxicity of isoflavones from Millettia dura
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Date
2021-08Author
Buyinza, Daniel
Yang, Li Jun
Derese, Solomon
Ndakala, Albert
Coghi, Paolo
Heydenreich, Matthias
Wong, Vincent K W
Möller, Heiko M
Yenesew, Abiy
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM).
Citation
Nat Prod Res . 2021 Aug;35(16):2744-2747Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10377]
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