Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis
LaCourse, Sylvia M
Richardson, Barbra A
Escudero, Jaclyn N
MetadataShow full item record
We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.
CitationLaCourse SM, Leon D, Panpradist N, Richardson BA, Maleche-Obimbo E, Mecha J, Matemo D, Escudero JN, Kinuthia J, Lutz B, John-Stewart G. Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis. Pediatr Infect Dis J. 2021 Jan;40(1):e43-e45. doi: 10.1097/INF.0000000000002936. PMID: 33055504; PMCID: PMC8336467.
University of Nairobi
RightsAttribution-NonCommercial-NoDerivs 3.0 United States
- Faculty of Health Sciences (FHS) 
The following license files are associated with this item: