Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis
Date
2021Author
LaCourse, Sylvia M
Leon, Daniel
Panpradist, Nuttada
Richardson, Barbra A
Maleche-Obimbo, Elizabeth
Mecha, Jerphason
Matemo, Daniel
Escudero, Jaclyn N
Kinuthia, John
Lutz, Barry
John-Stewart, Grace
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.
Citation
LaCourse SM, Leon D, Panpradist N, Richardson BA, Maleche-Obimbo E, Mecha J, Matemo D, Escudero JN, Kinuthia J, Lutz B, John-Stewart G. Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis. Pediatr Infect Dis J. 2021 Jan;40(1):e43-e45. doi: 10.1097/INF.0000000000002936. PMID: 33055504; PMCID: PMC8336467.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10387]
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