Potential pharmacologic interventions targeting TLR signaling in placental malaria
Date
2022Author
Kobia, Francis M
Maiti, Kaushik
Obimbo, Moses M
Smith, Roger
Gitaka, Jesse
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Complications from placental malaria cause poor pregnancy outcomes, including low birthweight, preterm delivery, and stillbirths. Many of these complications are driven by maternal innate proinflammatory responses to the sequestration of Plasmodium falciparum in the placenta. However, recent studies show that, in reaction to maternal innate immune responses that are detrimental to the fetus, the fetus mounts innate immune counter-responses that ameliorate pregnancy outcomes. Such fetal-maternal conflict in placental malaria has potential for pharmacologic modulation for better pregnancy outcomes. Here, we discuss placental malaria pathogenesis, its complications, and the role of innate immunity and fetal-maternal innate immune conflict in placental malaria. Finally, we discuss pharmacologic immunomodulatory strategies and agents with the potential to improve placental malaria outcomes.
Citation
Kobia FM, Maiti K, Obimbo MM, Smith R, Gitaka J. Potential pharmacologic interventions targeting TLR signaling in placental malaria. Trends Parasitol. 2022 Jul;38(7):513-524. doi: 10.1016/j.pt.2022.04.002. Epub 2022 May 7. PMID: 35537977.Publisher
University of Nairobi
Subject
fetal–maternal immune conflict; innate immune responses; placental malaria; pregnancy outcomes.Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10378]
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