Comparable Pregnancy Outcomes for Hiv-uninfected and Hiv-infected Women on Antiretroviral Treatment in Kenya
Date
2022Author
Mugo, Cyrus
Nduati, Ruth
Osoro, Eric
Nyawanda, Bryan O
Mirieri, Harriet
Hunsperger, Elizabeth
Verani, Jennifer R
Jin, Hafsa
Mwaengo, Dufton
Maugo, Brian
Machoki, James
Otieno, Nancy A
Ombok, Cynthia
Shabibi, Mufida
Okutoyi, Lydia
Kinuthia, John
Widdowson, Marc-Alain
Njenga, Kariuki
Inwani, Irene
Wamalwa, Dalton
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Background: The impact of Human Immunodeficiency Virus (HIV) on pregnancy outcomes for women on antiretroviral therapy (ART) in sub-Saharan Africa remains unclear.
Methods: Pregnant women in Kenya were enrolled in the second trimester and followed up to delivery. We estimated effects of treated HIV with three pregnancy outcomes: loss, premature birth, and low birthweight and factors associated with HIV-positive status.
Results: Of 2,113 participants, 311 (15%) were HIV-infected and on ART. Ninety-one of 1,762 (5%) experienced a pregnancy loss, 169/1,725 (10%) a premature birth (<37 weeks), and 74/1,317 (6%) had a low birthweight newborn (<2500 g).There was no evidence of associations between treated HIV infection and pregnancy loss (adjusted relative risk [aRR]: 1.19 [95% confidence interval: 0.65-2.16], p = 0.57), prematurity (1.09 [0.70-1.70], p = 0.69) and low birthweight (1.36 [0.77-2.40], p = 0.27). Factors associated with an HIV-positive status included older age, food insecurity, lower education level, higher parity, lower gestation at first antenatal clinic, anemia, and syphilis. Women who were overweight or underweight were less likely to be HIV infected compared to those with normal weight.
Conclusion: Currently treated HIV was not significantly associated with adverse pregnancy outcomes. HIV-infected women, however, had a higher prevalence of other factors associated with adverse pregnancy outcomes.
Citation
Mugo C, Nduati R, Osoro E, Nyawanda BO, Mirieri H, Hunsperger E, Verani JR, Jin H, Mwaengo D, Maugo B, Machoki J, Otieno NA, Ombok C, Shabibi M, Okutoyi L, Kinuthia J, Widdowson MA, Njenga K, Inwani I, Wamalwa D. Comparable pregnancy outcomes for HIV-uninfected and HIV-infected women on antiretroviral treatment in Kenya. J Infect Dis. 2022 Apr 11:jiac128. doi: 10.1093/infdis/jiac128. Epub ahead of print. PMID: 35403695.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10387]
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