Immunoepidemiologic profile of Chlamydia trachomatis infection:Importance of Heat-Shock Protein 60 and Interferon-γ
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Date
2005Author
Cohen, C.R
Koochesfahani, K.M
Meier, A S
Shen, C
Karunakaran, K
Ondondo, B
Kinyari, T
Mugo, N R
Nguti, R
Brunham., R C
Type
ArticleLanguage
enMetadata
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Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development.
Citation
J Infect Dis. 2005 Aug 15;192(4):591-9. Epub 2005 Jul 7Collections
- Faculty of Health Sciences (FHS) [10378]