Immunoepidemiologic profile of Chlamydia trachomatis infection:Importance of Heat-Shock Protein 60 and Interferon-γ
dc.contributor.author | Cohen, C.R | |
dc.contributor.author | Koochesfahani, K.M | |
dc.contributor.author | Meier, A S | |
dc.contributor.author | Shen, C | |
dc.contributor.author | Karunakaran, K | |
dc.contributor.author | Ondondo, B | |
dc.contributor.author | Kinyari, T | |
dc.contributor.author | Mugo, N R | |
dc.contributor.author | Nguti, R | |
dc.contributor.author | Brunham., R C | |
dc.date.accessioned | 2013-04-22T13:12:05Z | |
dc.date.available | 2013-04-22T13:12:05Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | J Infect Dis. 2005 Aug 15;192(4):591-9. Epub 2005 Jul 7 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16503 | |
dc.description.abstract | Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development. | en |
dc.language.iso | en | en |
dc.title | Immunoepidemiologic profile of Chlamydia trachomatis infection:Importance of Heat-Shock Protein 60 and Interferon-γ | en |
dc.title.alternative | importance of heat-shock protein 60 and interferon- gamma. | en |
dc.type | Article | en |
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