Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
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Date
2010-12Author
Guantai, Eric M.
Ncokazi, kanyile
Egan, Timonthy J.
Gut, Jiri
Rosenthal, Philip J.
Smith, peter J.
Chibale, Kelly
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides and terminal alkynes was applied as the hybridization strategy. Several chalcone-chloroquinoline hybrid compounds were found to be notably active, with compound 8b the most active, exhibiting submicromolar IC50 values against the D10, Dd2 and W2 strains of Plasmodium falciparum
URI
http://www.sciencedirect.com/science/article/pii/S0968089610009193http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16512
http://www.ncbi.nlm.nih.gov/pubmed/21044845
Publisher
Department of Medicine. College of Health Sciences. University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]