Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

dc.contributor.author	Guantai, Eric M.
dc.contributor.author	Ncokazi, kanyile
dc.contributor.author	Egan, Timonthy J.
dc.contributor.author	Gut, Jiri
dc.contributor.author	Rosenthal, Philip J.
dc.contributor.author	Smith, peter J.
dc.contributor.author	Chibale, Kelly
dc.date.accessioned	2013-04-22T13:46:47Z
dc.date.available	2013-04-22T13:46:47Z
dc.date.issued	2010-12
dc.identifier.uri	http://www.sciencedirect.com/science/article/pii/S0968089610009193
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16512
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/21044845
dc.description.abstract	A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides and terminal alkynes was applied as the hybridization strategy. Several chalcone-chloroquinoline hybrid compounds were found to be notably active, with compound 8b the most active, exhibiting submicromolar IC50 values against the D10, Dd2 and W2 strains of Plasmodium falciparum	en
dc.language.iso	en	en
dc.relation.ispartofseries	Vol.18, Issue 23, Pages 8243–8256 2010;
dc.title	Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds	en
dc.type	Article	en
local.publisher	Department of Medicine. College of Health Sciences. University of Nairobi	en