dc.contributor.author | Graham, SM | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Wener, MH | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola JO. | |
dc.contributor.author | Overbaugh, J | |
dc.contributor.author | McClelland, RS | |
dc.date.accessioned | 2013-04-24T12:17:11Z | |
dc.date.available | 2013-04-24T12:17:11Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | AIDS Res Hum Retroviruses. 2007 Oct;23(10):1197-200. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/17961104 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16598 | |
dc.description.abstract | We investigated the association between albumin levels and HIV-1 disease progression among 78 Kenyan women followed from before infection through a median of 70 months. With HIV-1 acquisition, median albumin decreased from 38.5 g/liter to 36.8 g/liter (p = 0.07) and the prevalence of hypoalbuminemia increased from 16% to 32% (p = 0.02). Each 1 g/liter decrease in albumin with HIV-1 acquisition was associated with a 13% increase (p = 0.01) in the risk of progressing to a CD4 count <200 cells/mul, after adjustment for set point plasma viral load. A decrease in albumin of over 10% was associated with a 3.5-fold increase in the risk of progressing to a CD4 count <200 cells/mul (95% CI 1.4-9.0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression | en |
dc.language.iso | en | en |
dc.title | A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression. | en |
dc.type | Article | en |
local.publisher | Department of Medicine, University of Washington, Seattle, Washington 98104, USA | en |
local.publisher | Department Medical of Microbiology, University of Nairobi | en |