• Login
    View Item 
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency

    Thumbnail
    View/Open
    Abstract.pdf (53.12Kb)
    Date
    1995-12
    Author
    Nduati, RW
    John, R C
    Richardson, BA
    Overbaugh, J
    Welch, M
    Ndinya-Achola, JO
    Moses, S
    Holmes, K
    Onyango, F
    Kreiss, J K
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    Breast milk samples from human immunodeficiency virus type 1 (HIV-1)-seropositive women were analyzed by polymerase chain reaction to determine the prevalence and determinants of HIV-1-infected cells in breast milk. Breast milk samples (212) were collected from 107 women, and 58% of the samples had detectable HIV-1 DNA. The proportion of HIV-1-infected cells in the milk samples ranged from 1 to 3255/10(4) cells. Breast milk samples with detectable HIV-1 DNA were more likely to be from women with absolute CD4 cell counts of < 400 (odds ratio, 3.1; 95% confidence interval [CI], 1.5-7.0). Severe vitamin A deficiency (< 20 micrograms/dL) was associated with a 20-fold increased risk of having HIV-1 DNA in breast milk among women with < 400 CD4 cells/mm3 (95% CI, 2.1-188.5). Women with CD4 cell depletion, especially those with vitamin A deficiency, may be at increased risk of transmitting HIV-1 to their infants through breast milk.
    URI
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17713
    http://www.ncbi.nlm.nih.gov/pubmed/7594703
    Citation
    Journal of Infectious Diseases.1995;172(6):1461-8
    Publisher
    Department of paediatrics, University of Nairobi
    Subject
    Human immunodeficiency virus
    Type 1-infected cells
    Breast Milk
    Immunosuppression
    Vitamin A deficiency.
    Description
    Journal article
    Collections
    • Faculty of Health Sciences (FHS) [10080]

    Copyright © 2019 
    University of Nairobi Library
    | UoN Quality Policy | Send Feedback
     

    Browse

    All of UoN Digital RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Copyright © 2019 
    University of Nairobi Library
    | UoN Quality Policy | Send Feedback