Persistently HIV-1 seronegative Nairobi sex workers are susceptible to in vitro infection
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Date
2000Author
Bienzle, Dorothee
MacDonald, Kelly S
Copeland, Karen F T
Bwayo, JJ
Plummer, Francis A
Rosenthal, Kenneth L
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVE:
To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level.
DESIGN:
In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance.
SETTING:
Samples were collected in a primary care clinic in Nairobi.
PATIENTS:
Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls.
INTERVENTIONS:
Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases.
RESULTS:
No inherent cellular resistance to infection was identified. CD8+ cells from a subset of subjects strongly inhibited viral replication.
CONCLUSIONS:
Lack of infection in this cohort was not attributable to factors inherent to CD4+ cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8+ cells and unique features of mucosal sites probably contribute to this state.
URI
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094779/http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/18278
http://www.ncbi.nlm.nih.gov/pubmed/18008255
Citation
Can J Infect Dis. 2000 Sep-Oct; 11(5): 259–263.Publisher
Department of Medical Microbiology
Collections
- Faculty of Health Sciences (FHS) [10377]