Persistently HIV-1 seronegative Nairobi sex workers are susceptible to in vitro infection
MacDonald, Kelly S
Copeland, Karen F T
Plummer, Francis A
Rosenthal, Kenneth L
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OBJECTIVE: To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level. DESIGN: In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance. SETTING: Samples were collected in a primary care clinic in Nairobi. PATIENTS: Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls. INTERVENTIONS: Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases. RESULTS: No inherent cellular resistance to infection was identified. CD8+ cells from a subset of subjects strongly inhibited viral replication. CONCLUSIONS: Lack of infection in this cohort was not attributable to factors inherent to CD4+ cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8+ cells and unique features of mucosal sites probably contribute to this state.
CitationCan J Infect Dis. 2000 Sep-Oct; 11(5): 259–263.
Department of Medical Microbiology