dc.contributor.author | Bienzle, Dorothee | |
dc.contributor.author | MacDonald, Kelly S | |
dc.contributor.author | Copeland, Karen F T | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, Francis A | |
dc.contributor.author | Rosenthal, Kenneth L | |
dc.date.accessioned | 2013-05-02T08:19:06Z | |
dc.date.available | 2013-05-02T08:19:06Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Can J Infect Dis. 2000 Sep-Oct; 11(5): 259–263. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094779/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/18278 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/18008255 | |
dc.description.abstract | OBJECTIVE:
To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level.
DESIGN:
In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance.
SETTING:
Samples were collected in a primary care clinic in Nairobi.
PATIENTS:
Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls.
INTERVENTIONS:
Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases.
RESULTS:
No inherent cellular resistance to infection was identified. CD8+ cells from a subset of subjects strongly inhibited viral replication.
CONCLUSIONS:
Lack of infection in this cohort was not attributable to factors inherent to CD4+ cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8+ cells and unique features of mucosal sites probably contribute to this state. | en |
dc.language.iso | en | en |
dc.subject | HIV Resistance | en |
dc.subject | Sex workers | en |
dc.subject | CD8 cell-mediated suppression | en |
dc.title | Persistently HIV-1 seronegative Nairobi sex workers are susceptible to in vitro infection | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology | en |