Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure
Date
2011Author
Lingappa, Jairam R
Petrovski, Slavé
Kiarie, James
Thomas, Katherine K
et al
Type
ArticleLanguage
enMetadata
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BACKGROUND:
Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use.
METHODS:
We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfected individuals was performed to identify factors associated with HIV-1 acquisition. In addition, a linear regression analysis was performed using SNP data from a subset (n = 403) of HIV-1 infected individuals to identify factors predicting plasma HIV-1 concentrations.
RESULTS:
After correcting for multiple comparisons, no SNPs were significantly associated with HIV-1 infection status or plasma HIV-1 concentrations.
CONCLUSION:
This GWAS controlling for HIV-1 exposure did not identify common host genotypes influencing HIV-1 acquisition. Alternative strategies, such as large-scale sequencing to identify low frequency variation, should be considered for identifying novel host genetic predictors of HIV-1 acquisition.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/22299http://www.ncbi.nlm.nih.gov/pubmed/22174851
Citation
PLoS One. 2011; 6(12): e28632.Publisher
Department of Obstetrics and Gynaecology
Description
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Collections
- Faculty of Health Sciences (FHS) [10378]