dc.contributor.author | Lingappa, Jairam R | |
dc.contributor.author | Petrovski, Slavé | |
dc.contributor.author | Kiarie, James | |
dc.contributor.author | Thomas, Katherine K | |
dc.contributor.author | et al | |
dc.date.accessioned | 2013-05-12T08:22:22Z | |
dc.date.available | 2013-05-12T08:22:22Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | PLoS One. 2011; 6(12): e28632. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/22299 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22174851 | |
dc.description | Full text | en |
dc.description.abstract | BACKGROUND:
Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use.
METHODS:
We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfected individuals was performed to identify factors associated with HIV-1 acquisition. In addition, a linear regression analysis was performed using SNP data from a subset (n = 403) of HIV-1 infected individuals to identify factors predicting plasma HIV-1 concentrations.
RESULTS:
After correcting for multiple comparisons, no SNPs were significantly associated with HIV-1 infection status or plasma HIV-1 concentrations.
CONCLUSION:
This GWAS controlling for HIV-1 exposure did not identify common host genotypes influencing HIV-1 acquisition. Alternative strategies, such as large-scale sequencing to identify low frequency variation, should be considered for identifying novel host genetic predictors of HIV-1 acquisition. | en |
dc.language.iso | en | en |
dc.subject | HIV-1 | en |
dc.subject | HIV serodiscordant couples | en |
dc.title | Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure | en |
dc.type | Article | en |
local.publisher | Department of Obstetrics and Gynaecology | en |