dc.contributor.author | Graham, SM | |
dc.contributor.author | Masese, L | |
dc.contributor.author | Gitau, Richardson Ba | |
dc.contributor.author | Mandaliya, Peshu | |
dc.contributor.author | Jaoko Walter G. | |
dc.contributor.author | Overbaugh, Mcclelland | |
dc.contributor.author | RS., R. K. N. | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.date.accessioned | 2013-05-30T06:33:36Z | |
dc.date.available | 2013-05-30T06:33:36Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Genital Ulceration Does Not Increase HIV-1 Shedding In Cervical Or Vaginal Secretions Of Women Taking Antiretroviral Therapy., Graham SM, Masese L, Gitau Richardson Ba Mandaliya Peshu Jaoko Ndinya-achola Overbaugh Mcclelland RS. R. K. N. , Sex Transm Infect. , Volume 87, Issue 2, P.114-7, (2011) | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/20980464 | |
dc.identifier.uri | Http://profiles.uonbi.ac.ke/jndinya/publications/genital-ulceration-does-not-increase-hiv-1-shedding-cervical-or-vaginal-secreti | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/27300 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081651/ | |
dc.description.abstract | OBJECTIVES:
Genital ulcer disease (GUD) is associated with increased HIV-1-RNA shedding in antiretroviral therapy (ART)-naive women. The effect of GUD on HIV-1 shedding among ART-treated women is not known. The objective of this study was to test the hypothesis that genital ulcerations increase genital HIV-1-RNA shedding in women receiving ART.
METHODS:
Eligible women initiated ART and attended monthly visits with inspection for genital lesions and collection of genital swabs. GUD cases diagnosed after 2 months or more on ART were included for analysis and served as their own controls. HIV-1 RNA was quantitated in specimens collected before, during and after GUD for all cases. The lower limit of quantitation was 100 HIV-1-RNA copies/swab. Using the pre-GUD visit as the reference, the detection of genital HIV-1 RNA before versus during and after GUD episodes was compared.
RESULTS:
36 women had GUD episodes after ART initiation. HIV-1 RNA was detected before, during and after GUD in cervical secretions from four (11%), one (3%) and six (17%) women, respectively, and in vaginal secretions from three (8%), four (11%) and four (11%) women, respectively. After adjustment for time on ART, there was no difference in the detection of cervical HIV-1 RNA before versus during GUD (adjusted OR 0.22, 95% CI 0.04 to 1.23). Likewise, GUD did not increase HIV-1 detection in vaginal secretions (adjusted OR 1.32, 95% CI 0.29 to 5.92).
CONCLUSIONS:
GUD did not significantly increase cervical or vaginal HIV-1 shedding. The results suggest that ART maintains its effectiveness for genital HIV-1 suppression despite GUD episodes. | |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy. | en |
dc.type | Article | en |
local.publisher | Faculty of medicine | en |