Increased Risk of infection with Human Immunodeficiency Virus Type 1 among Uncircumcised Men Presenting with Genital Ulcer Disease in Kenya Clin
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Date
1996-09Author
Tyndal, MW
Ronald, AR
Agoki, E
Malisa, W
Bwayo, JJ
Ndinya-Achola, JO
Moses, S
Plummer, FA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status and infection with HIV-1 among men with genital ulcer disease. Eight hundred and ten men participated in the study, of whom 190 (23%) were HIV-1-positive. A logistic regression model adjusted for behavioral and historical showed that HIV-1 positivity was independently associated with being uncircumcised (adjusted odds ratio [OR], 4.8; 95% confidence interval [CI], 3.3-7.2) and with a history of urethral discharge (adjusted OR, 2.0; 95% CI, 1.4-2.8). This association could not be explained by measures of sexual exposure to HIV-1 among this population. Male circumcision should be considered as an intervention strategy for AIDS control.
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http://profiles.uonbi.ac.ke/jndinya/publications/tyndal-mw-ronald-ar-agoki-e-malisa-w-bwayo-jj-ndinya-achola-jo-moses-s-plummer-http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28135
Citation
Clin Infect Dis. 1996 Sep;23(3):449-53.Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10377]