The HLA A2/6802 Supertype Is Associated With Reduced Risk Of Perinatal Human Immunodeficiency Virus Type 1 Transmission. J I

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Date
2001-02-01Author
Macdonald, K S
Embree, J E
Nagelkerke, N J
Castillo, J
Ramhadin, S
Njenga, S
Oyug, J
Ndinya-Achola, JO
Barber, B H
Bwayo, JJ
Plummer, F A
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P=.006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.
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Http://profiles.uonbi.ac.ke/jndinya/publications/macdonald-ks-embree-je-nagelkerke-nj-castillo-j-ramhadin-s-njenga-s-oyug-j-ndinhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28299
http://www.ncbi.nlm.nih.gov/pubmed/11133384
Citation
Macdonald Ks, Embree Je, Nagelkerke Nj, Castillo J, Ramhadin S, Njenga S, Oyug J, Ndinya-achola J, Barber Bh, Bwayo Jj, Plummer Fa.the Hla A2/6802 Supertype Is Associated With Reduced Risk Of Perinatal Human Immunodeficiency Virus Type 1 Transmission. J I, O., Prof. Ndinya-achola J. , J Infect Dis. 2001 Feb 1;183(3):503-6. Epub 2000 Dec 11., (2001)Publisher
University of Nairobi Institute of Tropica and Infectious Diseases(UNITID)
Collections
- Faculty of Health Sciences (FHS) [10214]