dc.contributor.author | Macdonald, K S | |
dc.contributor.author | Embree, J E | |
dc.contributor.author | Nagelkerke, N J | |
dc.contributor.author | Castillo, J | |
dc.contributor.author | Ramhadin, S | |
dc.contributor.author | Njenga, S | |
dc.contributor.author | Oyug, J | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Barber, B H | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, F A | |
dc.date.accessioned | 2013-05-31T10:14:53Z | |
dc.date.available | 2013-05-31T10:14:53Z | |
dc.date.issued | 2001-02-01 | |
dc.identifier.citation | Macdonald Ks, Embree Je, Nagelkerke Nj, Castillo J, Ramhadin S, Njenga S, Oyug J, Ndinya-achola J, Barber Bh, Bwayo Jj, Plummer Fa.the Hla A2/6802 Supertype Is Associated With Reduced Risk Of Perinatal Human Immunodeficiency Virus Type 1 Transmission. J I, O., Prof. Ndinya-achola J. , J Infect Dis. 2001 Feb 1;183(3):503-6. Epub 2000 Dec 11., (2001) | en |
dc.identifier.uri | Http://profiles.uonbi.ac.ke/jndinya/publications/macdonald-ks-embree-je-nagelkerke-nj-castillo-j-ramhadin-s-njenga-s-oyug-j-ndin | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28299 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11133384 | |
dc.description.abstract | Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P=.006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | The HLA A2/6802 Supertype Is Associated With Reduced Risk Of Perinatal Human Immunodeficiency Virus Type 1 Transmission. J I | en |
dc.type | Article | en |
local.publisher | Institute of Tropica and Infectious Diseases(UNITID) | en |