Vitamin A And Risk Of HIV-1 Seroconversion Among Kenyan Men With Genital Ulcers.
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Date
2001-03-30Author
Macdonald, K S
Malonza, I
Chen, D K
Nagelkerke, N J
Nasio, J M
Ndinya-Achola, JO
Bwayo, JJ
Sitar, D S
Aoki, F Y
Type
ArticleLanguage
enMetadata
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Background: Vitamin A is involved in normal immune function and the maintenance of mucosal integrity through complex effects on cellular differentiation. Objective: We sought to determine whether serum vitamin A levels were associated with altered susceptibility to primary infection with HIV-1 in men with high-risk sexual behaviour and genital ulcers who presented for treatment at an STD clinic in Nairobi, Kenya. Methods: HIV-1 seronegative men were prospectively followed. Vitamin A levels at study entry were compared among 38 men who HIV-1 seroconverted versus 94 controls who remained HIV seronegative. Results: Vitamin A deficiency (retinol less than 20 microg/dl) was very common and was present in 50% of HIV-1 seroconverters versus 76% of persistent seronegatives. Seroconversion was independently associated with a retinol level greater than 20 microg/dl (HR 2.43, 95% CI 1.25-4.70
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Http://profiles.uonbi.ac.ke/jndinya/publications/macdonald-ks-malonza-i-chen-dk-nagelkerke-nj-nasio-jm-ndinya-achola-j-bwayo-jj-http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28347
http://www.ncbi.nlm.nih.gov/pubmed/11317002.
Citation
Macdonald Ks, Malonza I, Chen Dk, Nagelkerke Nj, Nasio Jm, Ndinya-achola J, Bwayo Jj, Sitar Ds, Aoki Fy, Plummer Fa.vitamin A And Risk Of Hiv-1 Seroconversion Among Kenyan Men With Genital Ulcers.aids. 2001 Mar 30;15(5):635-9., O., Prof. Ndinya-achola J. , Aids. 2001 Mar 30;15(5):635-9., (2001)Publisher
University of Nairobi School of Public Health Centre for HIV Prevention and Research
Collections
- Faculty of Health Sciences (FHS) [10377]