| dc.contributor.author | Glazier, AP | |
| dc.contributor.author | Kokwaro, GO | |
| dc.contributor.author | Edwards, G | |
| dc.date.accessioned | 2013-06-06T09:53:49Z | |
| dc.date.available | 2013-06-06T09:53:49Z | |
| dc.date.issued | 1994-05 | |
| dc.identifier.citation | J Pharm Pharmacol. 1994 May;46(5):352-5 | en |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/8083805 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29141 | |
| dc.description.abstract | We have investigated the effect of experimental malaria infection on rat cytochrome P450-mediated drug metabolism using ethoxyresorufin and metoprolol as probe compounds. Malaria infection caused a significant reduction in total intrinsic clearance of ethoxyresorufin in both low and high parasitaemia malaria compared with control (control 18.7 +/- 7.2; low parasitaemia 10.5 +/- 4.1; high parasitaemia 4.3 +/- 1.4 mL min-1). However, clearance of metoprolol was unchanged in malaria infection compared with control (control 2.7 +/- 1.2; malaria 4.0 +/- 1.7 mL min-1). The change in clearance of ethoxyresorufin was the result of a decrease in Vmax, with no apparent change in Km. There was no change in either Vmax or Km of metoprolol. These results indicate a possible isozyme-selective effect of experimental malaria. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi. | en |
| dc.title | Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes | en |
| dc.type | Article | en |
| local.publisher | Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences | en |
