dc.contributor.author | Kokwaro, GO | |
dc.contributor.author | Szwandt, IS | |
dc.contributor.author | Glazier, AP | |
dc.contributor.author | Ward, SA | |
dc.contributor.author | Edwards, G | |
dc.date.accessioned | 2013-06-06T09:58:22Z | |
dc.date.available | 2013-06-06T09:58:22Z | |
dc.date.issued | 1993-12 | |
dc.identifier.citation | Xenobiotica. 1993 Dec;23(12):1391-7. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/8135041 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29145 | |
dc.description.abstract | 1. The effects of malaria infection due to Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of orally-administered caffeine (CA: 10 mg/kg) to its primary metabolites (theobromine (TB), paraxanthine (PX) and theophylline (TH)) were studied in 5-week-old male Wistar rats (n = 5 for each treatment). In separate experiments, the effects of malaria and endotoxin-induced fever on the clearance of i.v.-administered theophylline (TH; 15 mg/kg) were studied in another group of rats. 2. The ratios of CA to the three primary metabolites (TB/CA, PX/CA, PH/CA) determined in a single plasma sample obtained 3 h after CA administration were significantly reduced (p < 0.05) both by malaria and fever compared with control (saline) treatment. The clearance of TH determined from the concentration of TH in a single plasma sample obtained 6 h after TH administration was significantly reduced (p < 0.05) by fever but not malaria (4.0 +/- 0.7 ml/min/kg in controls; 4.2 +/- 0.5 in malaria; 2.4 +/- 0.4 in fever). 3. These results suggest that malaria and fever have different effects on CA and TH metabolism in vivo, probably as a result of different effects on the hepatic isozymes involved. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever | en |
dc.type | Article | en |
local.publisher | Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences | en |