Suppression of T-cell proliferative response in Plasmodium falciparum malaria patients--preliminary results.
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Date
1989Author
Chemtai, A K
Okelo, G B
Type
ArticleLanguage
enMetadata
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We report suppression of T-cell proliferative responses to P.falciparum specific antigen and mitogens. T-cells derived from malaria patients were co-cultured with P.falciparum antigen or mitogens and the T-cell activity determined by radioactive thymidine incorporation assay system. We found inhibition of T-cell responses to P.falciparum antigen in 13 out of 24 malaria patients studied. The suppression ranged from 4%-60%. Results of mitogenic responses of T-cells showed a wide variation. Suppression of concanavalin A (Con A) responses ranged from 48%-64% (4 out of 10 patients) while phytohaemagglutinin (PHA) responses varied from 4%-60% (8 out of 10 patients) and those of purified protein derivative (PPD) antigen from 12%-44% (3 out of 6 patients). Together, these preliminary results show a marked impairment in T-cell responses to parasite antigen and mitogens in P. falciparum infected patients
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http://www.ncbi.nlm.nih.gov/pubmed/2693067http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29239
Citation
East Afr Med J. 1989 Dec;66(12):787-91Collections
- Faculty of Health Sciences (FHS) [10378]