dc.contributor.author | Chemtai, A K | |
dc.contributor.author | Okelo, G B | |
dc.date.accessioned | 2013-06-06T12:07:39Z | |
dc.date.available | 2013-06-06T12:07:39Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | East Afr Med J. 1989 Dec;66(12):787-91 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2693067 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29239 | |
dc.description.abstract | We report suppression of T-cell proliferative responses to P.falciparum specific antigen and mitogens. T-cells derived from malaria patients were co-cultured with P.falciparum antigen or mitogens and the T-cell activity determined by radioactive thymidine incorporation assay system. We found inhibition of T-cell responses to P.falciparum antigen in 13 out of 24 malaria patients studied. The suppression ranged from 4%-60%. Results of mitogenic responses of T-cells showed a wide variation. Suppression of concanavalin A (Con A) responses ranged from 48%-64% (4 out of 10 patients) while phytohaemagglutinin (PHA) responses varied from 4%-60% (8 out of 10 patients) and those of purified protein derivative (PPD) antigen from 12%-44% (3 out of 6 patients). Together, these preliminary results show a marked impairment in T-cell responses to parasite antigen and mitogens in P. falciparum infected patients | en |
dc.language.iso | en | en |
dc.title | Suppression of T-cell proliferative response in Plasmodium falciparum malaria patients--preliminary results. | en |
dc.type | Article | en |