The antiplasmodial activity of isolates from Ajuga remota
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Date
2002-05Author
Kuria, KA
Chepkwony, H
Govaerts, C
Roets, E
Busson, R
De Witte, P
Zupko, I
Hoornaert, G
Quirynen, L
Maes, L
Janssens, L
Hoogmartens, J
Laekeman, G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagide (2) were evaluated for their in vitro antiplasmodial activity. Ajugarin-1 was moderately active, with an IC(50) of 23.0 +/- 3.0 microM, as compared to chloroquine (IC(50) = 0.041 +/- 0.003 microM) against the chloroquine-sensitive (FCA 20/GHA) strain of Plasmodium falciparum. Ergosterol-5,8-endoperoxide was about 3x as potent (IC(50) = 8.2 +/- 1.1 microM), while 8-O-acetylharpagide, whose structure was established by spectroscopic evidence, was inactive. Both ajugarin-1 and ergosterol-5,8-endoperoxide did not exhibit cytotoxicity against A431 (skin carcinoma) cell line, but 8-O-acetylharpagide was significantly cytotoxic. This iridoid glucoside, which has been formerly isolated from Ajuga decumbens, was identified in A. remota for the first time.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/12027771http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29313
Citation
J Nat Prod. 2002 May;65(5):789-93.Publisher
University of Nairobi. Faculty of Pharmacy, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]