The antiplasmodial activity of isolates from Ajuga remota
dc.contributor.author | Kuria, KA | |
dc.contributor.author | Chepkwony, H | |
dc.contributor.author | Govaerts, C | |
dc.contributor.author | Roets, E | |
dc.contributor.author | Busson, R | |
dc.contributor.author | De Witte, P | |
dc.contributor.author | Zupko, I | |
dc.contributor.author | Hoornaert, G | |
dc.contributor.author | Quirynen, L | |
dc.contributor.author | Maes, L | |
dc.contributor.author | Janssens, L | |
dc.contributor.author | Hoogmartens, J | |
dc.contributor.author | Laekeman, G | |
dc.date.accessioned | 2013-06-06T13:11:41Z | |
dc.date.available | 2013-06-06T13:11:41Z | |
dc.date.issued | 2002-05 | |
dc.identifier.citation | J Nat Prod. 2002 May;65(5):789-93. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/12027771 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29313 | |
dc.description.abstract | Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagide (2) were evaluated for their in vitro antiplasmodial activity. Ajugarin-1 was moderately active, with an IC(50) of 23.0 +/- 3.0 microM, as compared to chloroquine (IC(50) = 0.041 +/- 0.003 microM) against the chloroquine-sensitive (FCA 20/GHA) strain of Plasmodium falciparum. Ergosterol-5,8-endoperoxide was about 3x as potent (IC(50) = 8.2 +/- 1.1 microM), while 8-O-acetylharpagide, whose structure was established by spectroscopic evidence, was inactive. Both ajugarin-1 and ergosterol-5,8-endoperoxide did not exhibit cytotoxicity against A431 (skin carcinoma) cell line, but 8-O-acetylharpagide was significantly cytotoxic. This iridoid glucoside, which has been formerly isolated from Ajuga decumbens, was identified in A. remota for the first time. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | The antiplasmodial activity of isolates from Ajuga remota | en |
dc.type | Article | en |
local.publisher | Faculty of Pharmacy, University of Nairobi | en |
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