Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine.
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Date
1993Author
Lomo, P O
Makawiti, D W
Konji, V N
Type
ArticleLanguage
enMetadata
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1. The effect of trypanosome infection on rabbit liver mitochondrial oxidative phosphorylation was investigated, with and without thyroxine replacement. 2. State 3 respiration, respiratory control ratio (RCR) and ADP/O ratio were significantly reduced in mitochondria from trypanosome-infected animals whereas there was no change in state 4 respiration. 3. State 3 respiration, RCR and ADP/O ratio were not significantly altered in trypanosome-infected animals given thyroxine replacement therapy. 4. Trypanosome infection leads to impairment of mitochondrial integrity, apparently through lowered thyroxine levels. Replacement of thyroxine therefore sustains optimal mitochondrial respiratory activity.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8095444http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30298
Citation
Comp Biochem Physiol B. 1993 Jan;104(1):187-91.Publisher
Department of Biochemistry, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]