| dc.contributor.author | Lomo, P O | |
| dc.contributor.author | Makawiti, D W | |
| dc.contributor.author | Konji, V N | |
| dc.date.accessioned | 2013-06-07T15:32:59Z | |
| dc.date.available | 2013-06-07T15:32:59Z | |
| dc.date.issued | 1993 | |
| dc.identifier.citation | Comp Biochem Physiol B. 1993 Jan;104(1):187-91. | en |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/8095444 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30298 | |
| dc.description.abstract | 1. The effect of trypanosome infection on rabbit liver mitochondrial oxidative phosphorylation was investigated, with and without thyroxine replacement. 2. State 3 respiration, respiratory control ratio (RCR) and ADP/O ratio were significantly reduced in mitochondria from trypanosome-infected animals whereas there was no change in state 4 respiration. 3. State 3 respiration, RCR and ADP/O ratio were not significantly altered in trypanosome-infected animals given thyroxine replacement therapy. 4. Trypanosome infection leads to impairment of mitochondrial integrity, apparently through lowered thyroxine levels. Replacement of thyroxine therefore sustains optimal mitochondrial respiratory activity. | en |
| dc.language.iso | en | en |
| dc.title | Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine. | en |
| dc.type | Article | en |
| local.publisher | Department of Biochemistry, University of Nairobi | en |
