The effect of different apo(a) isoforms on plasminogen activation in black South African subjects.
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Date
2003-05Author
Choma, SR
Alberts, M
Potgieter, HC
Ojwang, PJ
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVE:
The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isofroms on plasminogen activation.
DESIGN:
A cross-sectional study.
SETTING:
A rural village (Dikgale district) in the Northen Province of South Africa.
SUBJECT:
A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study.
RESULTS:
The mean lipoprotein(a) [ Lp(a)] level in the subjects was 38.14 +/- 22.34 mg/dl. No association was found between Lp(a) isoforms. When the ratio of Lp(a):plasminogen was less then 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms.
CONCLUSION:
The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent of apo(a) size.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30395http://www.ncbi.nlm.nih.gov/pubmed/12844195
Citation
Cardiovascular journal of Southern Africa 2003, vol. 14, no3, pp. 120-124 [5 page(s)Publisher
University of Nairobi School of Health Science
Collections
- Faculty of Health Sciences (FHS) [10387]