| dc.contributor.author | Choma, SR | |
| dc.contributor.author | Alberts, M | |
| dc.contributor.author | Potgieter, HC | |
| dc.contributor.author | Ojwang, PJ | |
| dc.date.accessioned | 2013-06-10T06:59:24Z | |
| dc.date.available | 2013-06-10T06:59:24Z | |
| dc.date.issued | 2003-05 | |
| dc.identifier.citation | Cardiovascular journal of Southern Africa 2003, vol. 14, no3, pp. 120-124 [5 page(s) | en |
| dc.identifier.issn | 1015-9657 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30395 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/12844195 | |
| dc.description.abstract | OBJECTIVE:
The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isofroms on plasminogen activation.
DESIGN:
A cross-sectional study.
SETTING:
A rural village (Dikgale district) in the Northen Province of South Africa.
SUBJECT:
A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study.
RESULTS:
The mean lipoprotein(a) [ Lp(a)] level in the subjects was 38.14 +/- 22.34 mg/dl. No association was found between Lp(a) isoforms. When the ratio of Lp(a):plasminogen was less then 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms.
CONCLUSION:
The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent of apo(a) size. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi | en |
| dc.subject | Coagulation ; Lipids ; Africa ; Particle size ; South Africa ; Rural area ; Negroid ; Ethnic group ; Human ; Plasminogen ; Lipoprotein a ; Apolipoprotein ; | en |
| dc.title | The effect of different apo(a) isoforms on plasminogen activation in black South African subjects. | en |
| dc.type | Article | en |
| local.publisher | School of Health Science | en |
