Collagen Ialpha1 and vitamin D receptor gene polymorphisms in South African whites, blacks and Indians.
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Date
2001-11Author
Ojwang, PJ
Pegoraro, RJ
Rom, L
Lanning, P
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
To determine whether polymorphic differences exist between black, white and Indian South Africans in genes associated with bone mineral density and osteoporosis.
DESIGN:
Genes selected were the vitamin D receptor (Apa I and Taq I polymorphisms) and collagen (Sp I transcription factor polymorphism) using standard molecular biology techniques.
SETTING:
Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa.
SUBJECTS:
Healthy male and female blood donors living in the Durban metropolitan region, South Africa. The group comprised black Africans (n=264), white Caucasians (n=247) and Asians of Indian origin (n=194).
RESULTS:
No significant differences in genotypes were seen between white and Indian subjects. Blacks had a significantly higher frequency of the TT Taq I genotype and a significantly lower frequency of the Ss Sp I genotype. No ss genotype was detected in blacks.
CONCLUSION:
The very low frequency of the collagen Sp I s allele and higher frequency of the VDR T allele in blacks may be associated with the lower incidence of osteoporosis in this ethnic group.
URI
http://www.ajol.info/index.php/eamj/article/view/8951/1557http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30420
http://www.ncbi.nlm.nih.gov/pubmed/12219967
Citation
East African Medical Journal.2001 Nov;78(11):604-7.Publisher
University of Nairobi Department of Chemical Pathology,
Collections
- Faculty of Health Sciences (FHS) [10377]