dc.contributor.author | Ojwang, PJ | |
dc.contributor.author | Pegoraro, RJ | |
dc.contributor.author | Rom, L | |
dc.contributor.author | Lanning, P | |
dc.date.accessioned | 2013-06-10T07:20:12Z | |
dc.date.available | 2013-06-10T07:20:12Z | |
dc.date.issued | 2001-11 | |
dc.identifier.citation | East African Medical Journal.2001 Nov;78(11):604-7. | en |
dc.identifier.issn | 0012 835x | |
dc.identifier.uri | http://www.ajol.info/index.php/eamj/article/view/8951/1557 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30420 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/12219967 | |
dc.description.abstract | To determine whether polymorphic differences exist between black, white and Indian South Africans in genes associated with bone mineral density and osteoporosis.
DESIGN:
Genes selected were the vitamin D receptor (Apa I and Taq I polymorphisms) and collagen (Sp I transcription factor polymorphism) using standard molecular biology techniques.
SETTING:
Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa.
SUBJECTS:
Healthy male and female blood donors living in the Durban metropolitan region, South Africa. The group comprised black Africans (n=264), white Caucasians (n=247) and Asians of Indian origin (n=194).
RESULTS:
No significant differences in genotypes were seen between white and Indian subjects. Blacks had a significantly higher frequency of the TT Taq I genotype and a significantly lower frequency of the Ss Sp I genotype. No ss genotype was detected in blacks.
CONCLUSION:
The very low frequency of the collagen Sp I s allele and higher frequency of the VDR T allele in blacks may be associated with the lower incidence of osteoporosis in this ethnic group. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Collagen Ialpha1 and vitamin D receptor gene polymorphisms in South African whites, blacks and Indians. | en |
dc.type | Article | en |
local.publisher | Department of Chemical Pathology, | en |