Schistosoma mansoni in the baboon: modulation of pathology after vaccination with polyclonal anti-idiotypic antibodies.
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Date
1995Author
Nyindo, M
Borus, P K
Farah, I O
Oguya, F O
Makawiti, D W
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Vaccination of five baboons with an anti-idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated vaccine. Vaccination with the anti-idiotypic antibodies resulted in a significant reduction of pathology and granuloma size following challenge with live unattenuated cercariae. Results presented in this work are considered highly significant because the anti-idiotypic vaccine markedly influenced schistosomiasis morbidity which is the main consideration in this disease.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8552987http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30428
Citation
Schistosoma mansoni in the baboon: modulation of pathology after vaccination with polyclonal anti-idiotypic antibodies. Nyindo M, Borus PK, Farah IO, Oguya FO, Makawiti DW. Scand J Immunol. 1995 Dec;42(6):637-43.Publisher
Parasitology, National Museums of Kenya, Nairobi, Kenya.
Collections
- Faculty of Health Sciences (FHS) [10378]