Effect of murine schistosomiasis on hepatic cytochrome P-450 and microsomal protein
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Date
1986Author
Kyegombe, DB
Al-Mofleh, I
Al-Khuwaitir, S
Mahmoud, A
Al-Tuwaijri, A
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Experimental hepatic schistosomiasis was produced in CBA mice using a local strain of S. mansoni. A comparative study of the hepatic concentrations of cytochrome P-450 and microsomal protein in the control and infected animals was carried out. S. mansoni infection significantly (P less than 0.05) reduced the liver cytochrome P-450 and microsomal protein. This suggests impairment of drug metabolism in the liver of infected animals. The study calls attention to the possible clinical and pharmacokinetic implications of the late severe S. mansoni infection of the liver in man
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/3091977http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30614
Citation
Liver. 1986 Jun;6(3):167-72Publisher
Department of Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]