Effect of murine schistosomiasis on hepatic cytochrome P-450 and microsomal protein

dc.contributor.author	Kyegombe, DB
dc.contributor.author	Al-Mofleh, I
dc.contributor.author	Al-Khuwaitir, S
dc.contributor.author	Mahmoud, A
dc.contributor.author	Al-Tuwaijri, A
dc.date.accessioned	2013-06-10T09:43:48Z
dc.date.available	2013-06-10T09:43:48Z
dc.date.issued	1986
dc.identifier.citation	Liver. 1986 Jun;6(3):167-72	en
dc.identifier.uri	http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/3091977
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30614
dc.description.abstract	Experimental hepatic schistosomiasis was produced in CBA mice using a local strain of S. mansoni. A comparative study of the hepatic concentrations of cytochrome P-450 and microsomal protein in the control and infected animals was carried out. S. mansoni infection significantly (P less than 0.05) reduced the liver cytochrome P-450 and microsomal protein. This suggests impairment of drug metabolism in the liver of infected animals. The study calls attention to the possible clinical and pharmacokinetic implications of the late severe S. mansoni infection of the liver in man	en
dc.language.iso	en	en
dc.title	Effect of murine schistosomiasis on hepatic cytochrome P-450 and microsomal protein	en
dc.type	Article	en
local.publisher	Department of Medicine, University of Nairobi	en