Non-susceptibility genes to Bombyx densovirus type 1, Nid-1 and nsd-1, affect distinct steps of the viral infection pathway
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Date
2010Author
Kidokoro, K
Ito, K
Ogoyi, DO
Abe, H
Mita, K
Kadono-Okuda, K
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In the silkworm Bombyx mori, densovirus type 1 (BmDNV-1) replicates only in the midgut and causes fatal disease. Resistance to BmDNV-1 is determined by two genes, nsd-1 and Nid-1, respectively. Neither of them has been identified yet. We investigated the viral transcript by RT-PCR in inoculated silkworms carrying different sets of nsd-1 and Nid-1 genotype. BmDNV-1 transcript was not detected in nsd-1-carrying strains irrespective of existence of Nid-1 but clearly detected in strains carrying Nid-1 without nsd-1. The result suggests that nsd-1 blocks early step of infection. On the other hand, Nid-1 does not block cell and nucleus entry and viral transcription in nuclei but blocks later step in the viral infection cycle
URI
http://www.ncbi.nlm.nih.gov/pubmed/19836396http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30635
Citation
J Invertebr Pathol. 2010 Jan;103(1):79-81Publisher
Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan Department of Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]